RESEARCH CENTRE FOR BRAIN INJURY REHABILITATION

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ReCBIR RELATED UNIT PROFILES

 

 

   

Research Unit, Department of Neuroanaesthesia

 The Neuroscience Centre 

POTENTIAL RESEARCH COLLABORATION within ReCBIR
POTENTIAL EDUCATIONAL COLLABORATION within ReCBIR
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Copenhagen University Hospital (Rigshospitalet),

     
       

Blegdamsvej 9,

     
       

DK-2100 Copenhagen Ø

  phone: +45 28757618  
        Denmark   fax: +45  35327610  
                   
  HEAD OF UNIT:   Niels Vidiendal Olsen, MD, Dr. Med. Sci.   email: nvo@dadlnet.dk  
                 
  UNIT DESCRIPTION:  
      The Research Unit at the Department of Neuroanaesthesia was established April 1, 1999, as an effort to improve the experimental and clinical research activities at the department. Areas of interest include hypoxia, cerebral metabolism, cerebral and cerebrovascular inflammatory mechanisms, and cerebral water channels (aquaporins).  
               
         
  BRAIN INJURY RELATED RESEARCH:   Areas of interest include hypoxia, cerebral metabolism, cerebral and cerebrovascular inflammatory mechanisms, and cerebral water channels (aquaporins).  
     

The work of the Research Unit ranges from basic experimental research in animals or healthy human individuals to full-scale controlled studies in patients. Activities are based on a close collaboration with other groups within the University of Copenhagen and Rigshospitalet, i.e. the Department of Neurosurgery, the Neurobiology Research Unit, the Department of Pharmacology, and the Neuropsychiatry Research Unit. In addition, the Research Unit participates in international studies on high altitude physiology.

Supported by internal and external grants, the Research Unit has been able to implement modern scientific tools into the specific projects. These include intracerebral microdialysis for elaboration of metabolism and pharmacokinetics, direct measurements of cerebral oxygen tension, and advanced bio-techniques for measurements of tissue expression of specific proteins and their mRNA.

Currently, the main interest is focused on the potentiel use of human, recombinant erythropoietin (EPO) as an antiinflammatory and neuroprotective drug.

 
           
      Research facilities    
       

The Research Unit conducts its experimentel animal research within the facilities of the Neuropsychiatry Research Unit at Juliane Maries Vej, Rigshospitalet, and at facilities within the Department of Pharmacology at the Panum Institute.

 
           
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  POTENTIAL RESEARCH COLLABORATION WITHIN ReCBIR:   The research interests fall within the following ReCBIR research lines:  

1. MECHANISMS OF BRAIN INJURY

     

3. PHARMACOLOGICAL EFFECTS ON NEURAL TRAUMA AND BRAIN INJURY REHABILITATION

 
                   
  POTENTIAL EDUCATIONAL COLLABORATION  

The unit can contribute to the educational programmes of ReCBIR at the levels:

1. LEVELS PRIOR TO PH.D. STUDIES

2. PH.D. LEVEL

3. POSTDOCTORIAL LEVEL

Students and scientists of other ReCBIR units are welcome to spend periods of shorter or longer duration as visiting scientists/students. 

 
 
 
 
 
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  Examples of publications

 

     
 
  •    Poulsen TD, Klausen T, Richalet JP, Kanstrup IL, Fogh-Andersen N, Olsen NV. Plasma volume in acute hypoxia: comparison of a carbon monoxide rebreathing method and dye dilution with Evans’ Blue. European Journal of Applied Physiology 1998; 77: 457-61.
  •    Geertsen PF, von der Maase H, Olsen NV, Levin-Nielsen S, Leyssac PP. Renal haemodynamics, sodium and water reabsorption during continuous intravenous infusion of recombinant interleukin-2. Clinical Science 1998; 95: 73-81.
  •    Jespersen B, Randløv A, Abrahamsen J, Fogh-Andersen N, Olsen NV, Kanstrup IL. Acute cardiovascular effect of 1,25-dihydroxycholecalciferol in essential hypertension. American Journal of Hypertension 1998; 11: 659-66.
  •    Olsen NV, Christensen H, Kanstrup IL , Klausen T, Fogh-Andersen N, Plum I, Hansen JM. Effects of hyperventilation and hypocapnic/normocapnic hypoxemia on renal function and lithium clearance in humans. Anesthesiology 1998; 89: 1389-1400.
  •    Bestle MH, Olsen NV, Christensen P, Jensen BV, Bie P. Cardiovascular, endocrine and renal effects of urodilatin in normal humans. American Journal of Physiology 1999; 276: R684-95.
  •    Olsen NV, Jensen NG, Hansen JM, Christensen NJ, Fogh-Andersen N, Kanstrup IL. Non-steroidal antiinflammatory drugs and renal response to exercise: a comparison of indomethacin and nabumetone. Clinical Science 1999; 97; 457-65.
  •    Kanstrup IL, Poulsen TD, Hansen JM, Andersen LJ, Bestle MH, Christensen NJ, Olsen NV. Blood pressure and plasma catecholamines in acute and prolonged hypoxia. Effects of local hypothermia. Journal of Applied Physiology 1999; 87: 2053-8.
  •    Møller P, Loft S, Lundby C, Olsen NV. Acute hypoxia and hypoxic exercise induce DNA strand breaks and oxidative DNA damage in humans. FASEB Journal 2001; 15: 1181-86.
  •    Lundby C, Møller P, Kanstrup IL, Olsen NV. Heart rate response to hypoxic exercise: role of dopamine D2-receptors and effect of oxygen supplementation. Clinical Science 2001; 101: 377-83.
  •    Springborg JB, Ma X, Rochat P, Knudsen GM, Amtorp O, Paulson OB, Juhler M, Olsen NV. A single subcutaneous bolus of erythropoietin normalizes cerebral blood flow autoregulation after subarachnoid hemorrhage in rats. British Journal of Pharmacology 2002; 135: 823-29.
  •    Jürgens G, Christensen HR, Brøsen K, Sonne J, Loft S, Olsen NV. Acute hypoxia and cytochrome P450-mediated hepatic drug metabolism in humans. Clinical Pharmacology & Therapeutics 2002; 71: 214-20.
  •    Bestle MH, Olsen NV, Poulsen TD, Roach R, Fogh-Andersen N, Bie P. Prolonged hypobaric hypoxemia attenuates vasopressin secretion and the renal response to osmostimulation in men. Journal of Applied Physiology 2002; 92: 1911-22.
  •    Larsen DB, Jørgensen S, Olsen NV, Hansen SH, Larsen C. In vivo release of bupivakain from s.c. administered oily solution. Comparison with in vitro release. Journal of Controlled Release 2002; 81: 145-54.
  •    Jonassen TE, Græbe M, Promeneur D, Nielsen S, Christensen S, Olsen NV. LPS-induced acute renal failure in conscious rats: effects of specific phosphodiesterase type 3 and 4 inhibition. Journal of Pharmacology and Experimental Therapeutics 2002; 303: 364-74.
  •    Hasbak P, Lundby C, Olsen NV, Schifter S, Kanstrup IL. Calcitonin gene-related peptide (CGRP) and adrenomedullin release in humans: effects of exercise and hypoxia. Regulatory Peptides 2002; 108: 89-95.
  •    Robach P, Lafforgue E, Olsen NV, Déchaux M, Fouqueray B, Westerterp-Plantenga M, Westerterp K, Richalet JP. Recovery of plasma volume after one week of exposure to 4,350 m. Pflügers Archiv 2002; 444: 821-28.
  •    Hutchings M, Hesse B, Grønvall J, Olsen NV. Renal 131I-hippuran extraction in man: effects of dopamine. British Journal of Clinical Pharmacology 2002; 54: 675-77.
  •    Lindgaard L, Eskesen V, Gjerris F, Olsen NV. Familial aggregation of intracranial aneurysms in an Inuit population from Kalaallit Nunaat (Greenland). Neurosurgery 2003; 52: 357-63.
  •    Springborg JB, Sonne B, Frederiksen HJ, Foldager N, Poulsgaard L, Klausen T, Jørgensen OS, Olsen NV. Erythropoietin in the cerebrospinal fluid of patients with aneurysmal subarachnoid haemorrhage originates from the brain. Brain Research 2003; 984: 143-8.
  •    Græbe M, Brønd L, Christensen S, Nielsen S, Olsen NV, Jonassen TE. Chronic nitric oxide synthase inhibition exacerbates renal dysfunction in cirrhotic rats. American Journal of Physiology; Renal Physiology 2004; 286: F288-97.
  •    Mogensen J, Miskowiak K, Sørensen TA, Lind CT, Olsen NV, Springborg NV, Malá H. Erythropoietin improves place learning in fimbria-fornix transected rats and modifies the search pattern of normal rats. Pharmacology, Biochemistry and Behavior 2004; 77: 381-90.
  •    Liptrot M, Adams KH, Martiny L, Pinborg LH, Lonsdale MN, Olsen NV, Holm S, Svarer C, Knudsen GM. Cluster analysis in kinetic modelling of the brain: a noninvasive alternative to arterial sampling. Neuroimage 2004; 21: 483-93.
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