RESEARCH CENTRE FOR BRAIN INJURY REHABILITATION

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ReCBIR RELATED UNIT PROFILES

 

 

   

Laboratory of Neuroplasticity, Nencki Institute, Warsaw

POTENTIAL RESEARCH COLLABORATION within ReCBIR
POTENTIAL EDUCATIONAL COLLABORATION within ReCBIR
< CONTACT INFORMATION   Nencki Institute of Experimental Biology      
        3 Pasteur St.      
        02-093 Warsaw   phone: +48 22 668 61 82  
       

Poland

  fax: +48 22 822 53 42  
                   
  COORDINATOR:  

Prof. Malgorzata Kossut

  email: kossut@nencki.gov.pl  
                 
  INSTITUTE DESCRIPTION:   The Nencki Institute of Experimental Biology is a research institute belonging to Polish Academy of Sciences. One associated group, the Institute of Psychiatry and Neurology is a unit of Ministry of Health. The two institutes are joined together by common interests and a couple of joint research grants.  
 
                 
  BRAIN INJURY RELATED RESEARCH:   Neurorehabilitation Research Team consists of following participating units:  
      1. Laboratory of Neuroplasticity

Head: Prof. Malgorzata Kossut, Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, ul. Pasteura 3, 02-093 Warsaw, Poland   

Email: kossut@nencki.gov.pl                    phone: (48) 22 668 61 82                            fax: (48) 22 822 53 42

 
  Prof. Malgorzata Kossut
   
   
   
        Interests: Cellular and molecular mechanisms of plasticity of cerebral cortex. In the vibrissae to barrel cortex trigeminal pathway of mice and rats, restorative plasticity following cortical stroke, remodeling of cortical body maps after peripheral denervation, learning-induced cortical plasticity are monitored. Of particular interest is the role of the GABA-ergic system and its regulation by cortical plasticity. The effects of passive and active body stimulation and cortical remapping after stroke and its  pharmacological modulation are monitored. Neuronal plasticity of peristroke cortex is examined and attemps at stem cells therapy after stroke are made.  
 
 
 
 
 
 
 
        Methods: Brain mapping with 2-deoxyglucose, photothrombotic stroke, electrophysiology in brain slices, behavioral techniques, immunocytochemistry, in situ hybridization, anatomical tracing of connections  
 
 
        (Selected Publications -read more)  
           
      2. Laboratory of Molecular Basis of Brain Plasticity Head : Prof. Jolanta Skangiel-Kramska, Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, ul. Pasteura 3, 02-093 Warsaw, Poland

Email: jolak@nencki.gov.pl                    phone: (48) 22 5982446                             fax (48) 22 822 53 42

 
  Prof. Jolanta Skangiel-Kramska
   
   
   
        Interests: Neurochemical markers of brain plasticity. Changes are studied in the model system of vibrissal barrel pathway in mice after plastic changes induced by learning, sensory deprivation and stroke. Neurotransmitter receptor binding, extracellular matrix components and synaptic proteins in rat brain after stroke and neurorehabilitation are examined.  
 
 
 
 
        Methods: Receptor binding autoradiography, immunocytochemistry for presynaptic proteins and perineuronal nets, histochemistry for synaptic zinc, in situ chelation, in situ hybridization, brain mapping with 2-deoxyglucose  
 
 
        (Selected Publications -read more)  
                 
    I 3. Laboratory of Reinnervation Processes Head: Prof. Julita Czarkowska-Bauch, Department of Neurophysiology, Nencki Institute of Experimental Biology, ul. Pasterra 3, 02-093 Warsaw, Poland

Email: julita@nencki.gov.pl                   phone: (48) 22 5892438                            fax: (48) 22 822 53 42

 
  Prof. Julita Czakowska-Bauch                            
  Dr. Malgorzata Skup
   
   
   
        Interests: Mechanisms of response to injury of mature nervous system at the cellular and system level. Involvement of neurotrophins and cell adhesion molecules in neurodegeneration and recovery processes in spinal cord and supraspinal motor structures. Neurotrophins in brain and spinal cord following forced physical activity after stroke and spinal injury; functional recovery following spinal cord injury –effects of various physiotherapeutic strategies and their neurochemical correlates ;patterns of expression of transcription factors and prosurvival/proapoptotic proteins following injury are studied.  
 
 
 
 
 
 
        Methods: Histochemistry, immunocytochemistry, cell labeling, fibre tracing, neurochemistry (HPLC), molecular biology techniques (RT PCR, in situ hybridization), electrophysiology, behavioral techniques.  
 
 
        (Selected Publications -read more)  
                   
      4. Neurorehabilitation Clinic Head: Prof. Dr. Anna Czlonkowska, II. Neurology Clinic, Institute of Psychiatry and Neurology, Ul. Sobieskiego 9, Warszawa

Email:czlonkow@ipin.edu.pl                 phone: +46 22 642 6611                           fax: +48 22 842 40 23,                       

 
  Prof. Dr. Anna Czlonkowska,
  Dr J. Seniow
   
   
        Interests:  Neurorehabilitation after stroke and brain trauma, brain immunology, brain mechanisms of speach and aphasia, influence of Levodopa on recovery from aphasia.  
 
 
        Methods: Neuroreahbiltation therapy, physiotherapy, brain imaging, psychological testing, immunological techniques  
 
BACK TO TOP       (Selected Publications -read more)  
                   
  POTENTIAL RESEARCH COLLABORATION WITHIN ReCBIR:   The research interests fall within following ReCBIR research lines:  

2. NEURAL AND COGNITIVE MECHANISMS OF FUNCTIONAL RECOVERY AND REHABILITATION UPON BRAIN INJURY

 

3. PHARMACOLOGICAL EFFECTS ON NEURAL TRAUMA AND BRAIN INJURY REHABILITATION

5. SHORT- AND LONG-TERM BEHAVIOURAL AND COGNITIVE SYMPTOMS OF BRAIN INJURY
 
6. DEVELOPMENT OF NEUROPSYCHOLOGICAL REHABILITATION METHODS
7. SHORT- AND LONG-TERM OUTCOME OF POSTTRAUMATIC NEUROPSYCHOLOGICAL REHABILITATION
                   
  POTENTIAL EDUCATIONAL COLLABORATION   The unit is willing to contribute to the educational programs of ReCBIR at:

1. LEVELS PRIOR TO PH.D. STUDIES

2. PH.D. LEVEL

3. POSTDOCTORIAL LEVEL

The students and researchers of other units are welcome in the laboratories of the unit.

 
 
 
 
 
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  Examples of publications

 

     
  Laboratory of Neuroplasticity, Nencki Institute    
 

Siucinska, E.,Kossut, M. 1996 Short - lasting classical conditioning induces reversible changes of representational maps of vibrissae in mouse SI cortex. Cerebral Cortex, 6,3:506-513.

Kossut, M., Juliano, S.L. 1999. Anatomical correlates of representational map reorganization induced by partial vibrissectomy in the barrel cortex of adult mice. Neuroscience 92: 807-817.

Gierdalski, M., Jablonska, B., Smith, A., Skangiel-Kramska, J, Kossut, M. 1999. Deafferentation induced changes in GAD67 and GluR2 m RNA expression in mouse somatosensory cortex . Molecular Brain Res. 71:111-119.

Skibinska, A., Glazewski, S., Fox, ., Kossut, M.. 2000. Age dependent response of the mouse barrel cortex to sensory deprivation – a 2DG study. Exp. Brain Res. 132:134-138.

Gierdalski, M.Jablonska, B,Siucinska, E., Lech, M.,Skibinska,A.,Kossut, M. 2001. Rapid regulation of GAD67 mRNA and protein level in cortical neurons after sensory learning. Cerebral Cortex, 11:806-815.

Lech, M.,Skibinska, A.,Kossut, M. 2001. Delayed upregulation of GABAa alpha1 receptor subunit mRNA in somatosensory cortex of mice following learning-dependent plasticity of cortical representations. Molecuar Brain Res. 39:271-276.

Urban, J., Kossut, M., Hess, G. 2002. Long-term depression and long-term potentiation in horizontal connections of the barrel cortex. Europ. J. Neurosci. 16:1772-1776.

 
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  Laboratory of Molecular Basis of Brain Plasticity, Nencki Institute  
  Jabłońska B., Gierdalski M., Kossut M., Skangiel-Kramska J. Partial blocking of NMDA receptors reduces plastic changes induced by short-lasting classical conditioning in the SI barrel cortex of adult mice. Cereb. Cortex, (1999), 9: 222-231.

Majewska B., Skangiel-Kramska J. Phosphorylated MAP-1B isoforms in the developing mouse barrel cortex. Int. J. Devl. Neurosci.,( 2000), 18: 113-119.

Czupryn A., Skangiel-Kramska J. Deprivation and denervation differentially affect zinc-containing circuitries in the barrel cortex of mice.

Brain Res. Bull. (2001) 55: 287-295.

Czupryn A., Skangiel-Kramska J. Differential response of synaptic zinc levels to sensory deprivation in the barrel cortex of young and adult mice. Exp. Brain Res. (2001) 141: 586-572.

Nowicka D., Liguz-Lęcznar M., Skangiel-Kramska J. A surface antigen delineating a subset of neurons in the primary somatosensory cortex of the mouse. Acta Neurobiol. Exp. (2003), 63:185-195.

Czupryn A., Skangiel-Kramska J. Switch time-point for rapid experience-dependent changes in zinc-containing circuits in the mouse barrel cortex. Brain Res. Bull. (2003), 61:385-391.

 
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  Laboratory of Reinnervation Processes, Nencki Institute    
 

Jankowska E., Gladden, M.H.. Czarkowska-Bauch, J. (1998). Modulation of responses of feline gamma motoneurones by noradrenaline, tizanidine and clonidine. J. Physiol., 512, 2, pp. 521-531.

Sulejczak D., Skup M. (2000) Axoplasmic localization of NFB p65 subunit in the rat brain. Acta Neurobiol. Exp. 60: 217.

Skup M., J. Czarkowska-Bauch J., Dwornik A., Macias M., Sulejczak D., Wiater M. (2000) Locomotion induces changes in TrkB receptors in small diameter cells of the spinal cord. Acta Neurobiol. Exp. 60: 371.

Skup M., Dwornik, A., Macias, M., Sulejczak, D., Wiater, M. Czarkowska-Bauch, J. (2002) Long-term locomotor training up-regulates TrkB FL receptor-like proteins, brain-derived neurotrophic factor, and neurotrophin 4 with different topographies of expression in oligodendroglia and neurons in the spinal cord. Exp. Neurol. 176, 289-307.

Macias M., Fehr S., Dwornik A., Sulejczak D., M. Wiater M., Czarkowska-Bauch J., Skup M., Schachner M. (2002) Exercise increases mRNA level for adhesion molecules N-CAM and L1 correlating with BDNF response. NeuroReport, 13 (18): 2527 – 2530.

Sulejczak D., Czarkowska-Bauch, J., Macias, M. Skup M. (2004) Bcl-2 and Bax proteins are increased in neocortical but not in thalamic apoptosis following devascularizing lesions of the cerebral cortex in the rat: an immunohistochemical study. Brain Res. 1006/2, 133-149.

 
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  Neurology Clinic and Neurorehabilitation Clinic, Instittute of Psychiatry and Neurology  
  .A. Paz, U.Fiszer, J.Zaborski, J.Korlak, A.Czlonkowski, A. Czlonkowska, Phenotyping analysis of peripheral blood leukocytes in patients with multiple sclerosis
Eur. J. Neurol. 1999, 6,347-352.

J.Zielińska, D.Ryglewicz, E.Wierzchowska, W.Lechowicz, D.B.Hier, A.Czlonkowska, Anticardiolipin antibodies are an independent risk factor for ischemic stroke. Neurol. Res. 1999, 21, 653-657.

D.Ryglewicz, D.Hier, M.Wiszniewska, S.Cichy, W.Lechowicz. A. Czlonkowska, Ischemic strokes are more severe in Poland than in the United States. Neurology 2000, 54, 513-515.

W.Palasik, U.Fiszer, W.Lechowicz, A.Czlonkowska, Changes of levels of Il-6, Il-8 and P-selection in the blood of patients with acute ischaemic stroke. Central European. Journal of Immunology 2001, 26, 24-27.

G.Gromadzka, J.Zielińska, D.Ryglewicz, U.Fiszer, A. Czlonkowska, Elevated levels of anti-heat-shock protein antibodies in patients with cerebral ischemia.Cerebrovasc. Dis. 2001, 12, 235-239

Tarncka, G. Gromadzka, A. Czlonkowska Increased circulating immune complexes in acute stroke: the triggering role of Chlamydia pneumoniae and cytomegalovirus.B. Stroke 2002, 4, 936-940.

SeniowJ, Bak T, Gajda J, Poniatowska R, Czlonkowska A. 2002 Cognitive functioning in neurologically symptomatic and asymptomatic forms of Wilson,s disease. Mov. Disord. 17:1077-83.

Seniow, J., Polanowska, R, Mandat, k, Laudanski, K. 2003 The cognitive impairments due to occipito-parietal injury after gunshot: A succesful neurorehabilitation case study. Brain Inj.17: 701-13.

 
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