RESEARCH CENTRE FOR BRAIN INJURY REHABILITATION

HOME ABOUT ReCBIR GOALS NETWORK RESEARCH LINES/PROJECTS EDUCATION PUBLICATIONS LINKS CONTACT  

ReCBIR RELATED UNIT PROFILES

 

 

   

The Unit for Cognitive Neuroscience

(UCN)

POTENTIAL RESEARCH COLLABORATION within ReCBIR
POTENTIAL EDUCATIONAL COLLABORATION within ReCBIR
< CONTACT INFORMATION  

Department of Psychology

     
       

University of Copenhagen

     
       

Oester Farimagsgade 5A, Building 10

  phone: +45 35324873  
       

DK-1353 Copenhagen K, Denmark

  fax: +45 35324802  
                   
  HEAD OF DEPARTMENT:   Professor, Dr. Jesper Mogensen   email:  jesper.mogensen@psy.ku.dk  
                 
  Deputy Head:   Hana Malá, Cand.psych.   e-mail: hana.mala@psy.ku.dk  
                 
  DEPARTMENT DESCRIPTION:          
General:
     

The Unit for Cognitive Neuroscience (UCN) is a scientific unit with a focus on basic, neuroscientific research with implications for the understanding of the human brain in health and disease.

 
     

The research of UCN includes the anatomy, chemistry, and electrophysiology of the brain. But the major research areas fall within studies of the functions of brain structures and the structurally and/or chemically defined systems of the brain.

The major research goals of the UCN fall within three categories:

    • The understanding of the normal human brain.
    • The understanding of the diseases and traumatic conditions of the human brain.
    • The development of ways to prevent, cure, or alleviate the consequence of pathological conditions of the human brain.

A basic principle of UCN is scientific independence – that is: the ability to plan, conduct, and publish projects independently of interests external to UCN.

UCN has for all of its history been associated with institutes of the University of Copenhagen. It is, however, only since 1998 that UCN has been an integral part of this university. UCN is mainly – and throughout most of its existence exclusively – financed by grants from governmental and private foundations.

The staff of the UCN includes members of a broad spectrum of scientific disciplines – however with an emphasis on the areas of medicine and psychology.

 
 
      Methods:          
       

UCN is specialised in the application of animal models within cognitive neuroscience.

Of special relevance to the areas covered by ReCBIR are:

- A broad spectrum of (partly UCN-developed) surgical and pharmacological methods allowing the creation of specific animal (mainly rat) models of brain injuries.

- A broad spectrum of behavioural methods (many within the areas of spatial learning, memory, problem solving, and orientation) allowing a detailed analysis of the cognitive symptoms upon brain injury – and the cognitive mechanisms of posttraumatic recovery and rehabilitation.

- A number of UCN-developed pharmacological and/or surgical "challenge" techniques allowing the analysis of the structural and/or neurochemical substrate of posttraumatic functional recovery and rehabilitation.

- A number of UCN-developed behavioural "challenge" techniques allowing the analysis of the cognitive mechanisms of posttraumatic functional recovery and rehabilitation.

 
                   
  BRAIN INJURY RELATED RESEARCH:  

The brain injury and brain injury rehabilitation related research lines of UCN are primarily basic (mostly animal model based) research dealing with issues primarily within the categories:

 
     

1. Cognitive and behavioural symptoms of focal and/or neurochemically specific brain injury.

2. The neural substrate and cognitive mechanisms of functional recovery and rehabilitation upon brain injury.

3. The development and evaluation of pharmacological therapies able to reduce the primary and secondary consequences of the initial trauma, and/or support, promote, and/or complete the posttraumatic functional recovery and rehabilitation.

4. The development and/or evaluation of cognitive and behavioural methods of posttraumatic cognitive and behavioural recovery and rehabilitation.

 
BACK TO TOP          
         
  POTENTIAL RESEARCH COLLABORATION WITHIN ReCBIR:   Within the ReCBIR research lines, UCN can primarily contribute to:  
     
1. MECHANISMS OF BRAIN INJURY
 
      
2. NEURAL AND COGNITIVE MECHANISMS OF FUNCTIONAL RECOVERY AND REHABILITATION UPON BRAIN INJURY
 

3. PHARMACOLOGICAL EFFECTS ON NEURAL TRAUMA AND BRAIN INJURY REHABILITATION

 

4. DEVELOPMENT AND EVALUATION OF ACUTE AND EARLY-POSTACUTE INTERVENTIONS PROMOTING SUBSEQUENT REHABILITATION

5. SHORT- AND LONG-TERM BEHAVIOURAL AND COGNITIVE SYMPTOMS OF BRAIN INJURY
 
6. DEVELOPMENT OF NEUROPSYCHOLOGICAL REHABILITATION METHODS
7. SHORT- AND LONG-TERM OUTCOME OF POSTTRAUMATIC NEUROPSYCHOLOGICAL REHABILITATION
                   
  POTENTIAL EDUCATIONAL COLLABORATION  

UCN can contribute to the educational programmes of ReCBIR at the levels:

1. LEVELS PRIOR TO PH.D. STUDIES

2. PH.D. LEVEL

3. POSTDOCTORIAL LEVEL

Students and scientists of other ReCBIR units are welcome to spend periods of shorter or longer duration as visiting scientists/students within UCN.

 
 
 
 
 
BACK TO TOP          
           
  Examples of publications

 

       
  Mogensen, J., Lauritsen, K.T., Elvertorp, S., Hasman, A., Moustgaard, A. & Wörtwein, G. Place learning and object recognition by rats subjected to transection of the fimbria-fornix and/or ablation of the prefrontal cortex. Brain Research Bulletin, 2004, 63, 217-236.

Mogensen, J., Miskowiak, K., Sørensen, T.A., Lind, C.T., Olsen, N.V., Springborg, J.B. & Malá, H. Erythropoietin improves place learning in fimbria-fornix transected rats and modifies the search pattern of normal rats. Pharmacology, Biochemistry and Behavior, 2004, 77, 381-390.

Mogensen, J., Malá, H., Vangkilde, S.A. & Nordfang, M. Retention and reversals of a sequential behavioural task after prefrontal cortical lesions in the rat. Homeostasis in Health and Disease, 2003, 42, 110-121.

Mogensen, J., Moustgaard, A., Møller, S.B., Førster, P. & Horsager, M. Impaired acquisition and retension of an egocentric spatial orientation task in a water maze by rats subjected to ablations of the prefrontal cortex. Homeostasis in Health and Disease, 2003, 42, 97-109.

Mogensen, J., Svendsen,G., Lauritsen,K.T., Ermens,P., Hasman,A., Elvertorp,S., Plenge, P., Mellerup, E.T. & Wörtwein, G. Associative and non-associative learning after chronic imipramine in rats. Pharmacology, Biochemistry & Behavior, 2003, 76, 197-212. 

Mogensen, J., Montero, A. and Wörtwein, G., Analysis of response patterns during prefrontally ablated rats' acquisition of an "egocentric" spatial task in an 8-arm radial-maze. Homeostasis in Health and Disease, 2003, 42, 52-59.  

Mogensen, J., Døngart, R., Wegener, J. and Malá, H., Place learning with and without observation from the goal position: effects of prefrontal cortical ablations in the rat. Homeostasis in Health and Disease, 2003, 42, 38-51.  

Mogensen, J., Jespersen, K.H., Nielsen, N.H. & Malá, H., Shifts between responses and strategies in rats after ablations of the prefrontal cortex. Homeostasis in Health and Disease, 2003, 42, 29-37

Mogensen, J., Mellentin, C. and Moustgaard, A., Virtually unimpaired acquisition of a sequential behavioural task after prefrontal cortical lesions in the rat. Homeostasis in Health and Disease, 2003, 42, 18-28

Mogensen, J., Wörtwein, G., Plenge, P. & Mellerup, E.T., Serotonin, locomotion, exploration, and place recall in the rat. Pharmacology, Biochemistry & Behavior, 2003, 75, 381-395

Mogensen, J., Animal models in neuroscience. In: Hau, J. & van Hoosier, G. (Eds.)  Handbook of Laboratory Animal Science, Second Edition, Volume 2. Boca Raton, FL: CRC Press LLC, 2003, pp. 95-109.

Mogensen, J., Christensen, L.H., Johansson, A., Wörtwein, G., Bang, L.E. & Holm, S., Place learning in scopolamine treated rats: the roles of distal cues and catecholaminergic mediation.  Neurobiology of Learning and Memory, 2002, 78, 139-166. 

Glenthøj, B.Y., Mogensen, J., Laursen, H. & Hemmingsen, R., Dopaminergic sensitization of rats with and without early prefrontal lesions: Implications for the pathogenesis of schizophrenia.  International Journal of Neuro­psychopharmacology, 1999, 2, 271-281. 

Wörtwein, G., Gustafson, B., Hansen, K.L. & Mogensen, J., Behavioral symptoms in adult rats after postnatal L-nitro-arginine. International Journal of Developmental Neuroscience, 1997, 15, 147-154. 

Mogensen, J., Ermens, P., Moustgaard, A. & Wörtwein, G., Place learning in prefrontally ablated and L-nitro-arginine treated rats. Homeostasis, 1996, 37, 193-203. 

Négyessy, L., Takács, J., Mogensen, J., Divac, I. & Hámori, J., Synaptic reorgan­is­ation of the mediodorsal thalamic nucleus in adult rat following chronic prefrontal cortical lesions. Journal of Brain Research, 1995, 36, 433-441. 

Mogensen, J., Pedersen, T.K., Holm, S. & Bang, L.E., Prefrontal cortical mediation of rats' place learning in a modified water maze. Brain Research Bulletin, 1995, 38, 425-434. 

Mogensen, J., Wörtwein, G., Gustafson, B. & Ermens, P., L-Nitroarginine reduces hippocampal mediation of place learning in the rat. Neurobiology of Learning and Memory, 1995, 64, 17-24. 

Wörtwein, G., Saerup, L.H., Charlottenfeld-Starpov, D. & Mogensen, J., Place learning by fimbria-fornix transected rats in a modified water maze. Inter­na­tional Journal of Neuro­science, 1995, 82, 71-81. 

Mogensen, J., Hasman, A. & Wörtwein, G., Place learning during inhibition of nitric oxide synthase in the rat. Homeostasis, 1995, 36, 12-18. 

Mogensen, J., Wörtwein, G., Hasman, A., Nielsen, P. & Wang, Q., Functional and neurochemical profile of place learning after L-nitro-arginine in the rat. Neurobiology of Learning and Memory, 1995, 63, 54-65.

Wörtwein, G., Mogensen, J., Williams, G., Carlos, J.H. & Divac, I., Cortical area in the rat that mediates visual pattern discrimination. Acta Neurobiologiae Experimentalis, 1994, 54, 365-376. 

Wörtwein, G., Mogensen, J. & Divac, I., Retention and relearning of spatial delayed alternation in rats after ablation of the prefrontal or total non­-prefrontal isocortex. Behavioural Brain Research, 1994, 63, 127-131. 

Mogensen, J. & Holm, S., The prefrontal cortex and variants of sequential behav­iour: Indications of functional dif­ferentiation between subdivisions of the rat's pre­fron­tal cortex. Behavioural Brain Research, 1994, 63, 89-100. 

Mogensen, J. Animal models in neuroscience. In: Svendsen, P. & Hau, J. (Eds.), Handbook of Laboratory Animal Science, Volume II, Animal Models. New York: CRC Press, Inc. 1994, pp. 125-136.

Mogensen, J., Pedersen, T.K. & Holm, S., Effects of chronic imipramine on exploration, locomotion, and food/water intake in rats. Pharmacology, Biochemistry & Behavior, 1994, 47, 427-435. 

Mogensen, J., Pedersen, S.L. & Jørgensen, O.S., Electrocon­vul­sive stimulations, learning, and protein changes in the rat brain. Pharmacol­ogy, Biochemistry & Behavior, 1994, 47, 647-657. 

Holm, S. & Mogensen, J., Contralateral somatosensory neglect in unrestrained rats after lesion of the parietal cortex of the left hemi­sphere. Acta Neurobiologiae Experimentalis, 1993, 53, 569-576. 

Mogensen, J., The prefrontal systems of young and "middle-aged" rats: acquisi­tion and retention of delayed alternation. Homeostasis, 1993, 34, 148-153. 

Mogensen, J., Geoffroy, M., Bek, T., Fahrenkrug, J. & Rafael­sen, O.J., Presumed isolation stress but not reserpine affects cerebral vasoactive intestinal polypeptide (VIP) in the rat. Homeo­stasis, 1993, 34, 137-142. 

Mogensen, J. & Divac, I., Behavioural changes after ablation of subdivisions of the rat prefrontal cortex. Acta Neurobiologiae Experimentalis, 1993, 53, 439-449.

Wörtwein, G., Mogensen, J. & Divac, I., Retention and relearning of spatial delayed alternation in rats after combined or sequential lesions of the prefrontal and pari­etal cortex. Acta Neuro­biologiae Experimentalis, 1993, 53, 357-366. 

Mogensen, J. & Divac, I., Behavioural effects of ablation of the pigeon­-equivalent of the mammalian prefrontal cor­tex. Behavioural Brain Research, 1993, 55, 101-107. 

Mogensen, J., Björklund, A. & Divac, I., Catecholamines and DOPAC in cor­tical and neostriatal regions during rats' learning of delayed alter­na­tion. Acta Neuro­biologiae Experimentalis, 1992, 52, 49-56. 

Ulrichsen, J., Mogensen, J., Laursen, H., Barry, D. & Hem­mingsen, R., Behav­ioral impairment during thiamine defici­ency and ethanol intoxica­tion in rats with­out detectable neuropathol­ogic­al changes. Neuro­science Research Communica­tions, 1991, 9, 99-108. 

Mogensen, J., Influences of the rearing conditions on func­tional properties of the rat's prefrontal system. Behavioural Brain Research, 1991, 42, 135-142. 

Holm, S. & Mogensen, J., Prefrontal neglect in the rat. Scandinavian Journal of Laboratory Animal Science, 1989, 16, Supplement 1, 59-62. 

Mogensen, J. & Holm, S., Basic research and animal models in neuroscience - the necessity of "co-evolution". Scand­inavian Journal of Laboratory Animal Science, 1989, 16, Supplement 1, 51-57. 

Geoffroy, M. & Mogensen, J., Differential recovery in measures of explora­tion/loco­motion after a single dosage of reser­pine in the rat. Acta Neuro­biol­ogiae Experimentalis, 1988, 48, 263-275. 

Ulrichsen, J., Laursen, H., Mogensen, J., Clemmesen, L. & Hem­ming­sen, R., Impaired active avoidance performance in thia­mine deficient rats with­out detect­able neuropathol­ogical changes.  Neuroscience Re­search Com­munications, 1987, 1, 65-70. 

Mogensen, J., Iversen, I.H. & Divac, I., Neostriatal lesions impaired rats' delayed alternation performance in a T-maze but not in a two-key operant chamber. Acta Neurobiologiae Experimentalis, 1987, 47, 45-54. 

Mogensen, J. & Jørgensen, O.S., Protein changes in the rat's prefrontal and "infero­temporal" cortex after exposure to visual problems. Pharmacology, Biochemistry & Behavior, 1987, 26, 89-94. 

Jørgensen, O.S., Mogensen, J. & Divac, I., The N-CAM D2-pro­tein as marker for synaptic remodelling in the red nu­cleus. Brain Research, 1987, 405, 39-45. 

Divac, I. & Mogensen, J., Modularity of the prosencephalon: The vertical systems. In: Will, B.E., Schmitt, P. & Dalrymple-Alford, J.C. (Eds.) Brain Plasticity, Learn­ing, and Memory. New York: Plenum Press. 1985, pp. 205-210.

Divac, I., Petrovic-Minic, B. & Mogensen, J., Focal corti­cal seizures pre­vent HRP and HRP-WGA labeling only in neurons bidirectionally con­nected to the cortex. Brain Research, 1984,  311, 189-193. 

Mogensen, J. & Divac, I., Sequential behavior after modified prefrontal lesions in the rat.  Physiolog­ical Psychol­ogy, 1984, 12, 41-44. 

Mogensen, J. & Divac, I., The prefrontal "cortex" in the pigeon. Behavioral evi­dence. Brain, Behavior and Evolution, 1982, 21, 60-66. 

Mogensen, J., Jørgensen, O.S. & Divac, I., Synaptic proteins in frontal and control brain regions of rats after exposure to spatial problems. Behav­ioural Brain Re­search, 1982, 5, 375-386. 

 

 

 
 
BACK TO TOP          
                   
HOME ABOUT ReCBIR GOALS NETWORK PROJECTS EDUCATION PUBLICATIONS LINKS CONTACT